1,946 research outputs found
Triplanar Model for the Gap and Penetration Depth in YBCO
YBaCuO_7 is a trilayer material with a unit cell consisting of a CuO_2
bilayer with a CuO plane of chains in between. Starting with a model of
isolated planes coupled through a transverse matrix element, we consider the
possibility of intra as well as interplane pairing within a nearly
antiferromagnetic Fermi liquid model. Solutions of a set of three coupled BCS
equations for the gap exhibit orthorhombic symmetry with s- as well as d-wave
contributions. The temperature dependence and a-b in plane anisotropy of the
resulting penetration depth is discussed and compared with experiment.Comment: To appear in Physical Review B1 01Mar97; 12 pages with 10 figures;
RevTeX+eps
Fatness, fitness, and cardiometabolic risk factors in middle-aged white men.
The objective was to test the hypothesis that traditional and novel cardiometabolic risk factors would be significantly different in groups of men of different fatness and fitness. Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, insulin, high-sensitivity C-reactive protein, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, leptin, adiponectin, tumor necrosis factor-α, interleukin-6, interleukin-10, fibrinogen, and insulin resistance were assessed in 183 nonsmoking white men aged 35 to 53 years, including 62 who were slim and fit (waist girth ≤90 cm and maximal oxygen consumption [VO(2)max] above average), 24 who were slim and unfit (waist girth ≤90 cm and VO(2)max average or below), 39 who were fat and fit (waist girth ≥100 cm and VO(2)max above average), and 19 who were fat and unfit (waist girth ≥100 cm and VO(2)max average or below). Seventy-six percent gave blood on 2 occasions, and the average of 1 or 2 blood tests was used in statistical tests. Waist girth (centimeters) and fitness (milliliters of oxygen per kilogram of fat-free mass) were associated with high-density lipoprotein cholesterol, leptin, and insulin resistance after adjustment for age, saturated fat intake, and total energy intake. High-density lipoprotein cholesterol, triglycerides, alanine aminotransferase, and insulin resistance were significantly different in men who were fat and fit and those who were fat and unfit. These data suggest that differences in lipid and lipoprotein concentrations, liver function, and insulin resistance may explain why the risks of chronic disease are lower in men who are fat and fit than those who are fat and unfit
Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding : systematic review and meta-analysis of data from individual patients
Peer reviewedPublisher PD
c-axis Josephson Tunnelling in Twinned and Untwinned YBCO-Pb Junctions
Within a microscopic two band model of planes and chains with a pairing
potential in the planes and off diagonal pairing between planes and chains we
find that the chains make the largest contribution to the Josephson tunnelling
current and that through them the d-wave part of the gap contributes to the
current. This is contrary to the usual assumption that for a d-wave tetragonal
superconductor the c-axis Josephson current for incoherent tunnelling into an
s-wave superconductor is zero while that of a d-wave orthorhombic
superconductor with a small s-wave component to its gap it is small but
non-zero. Nevertheless it has been argued that the effect of twins in YBCO
would lead to cancellation between pairs of twins and so the observation of a
current in c-axis YBCO-Pb experiments is evidence against a d-wave type order
parameter. We argue that both theory and experiment give evidence that the two
twin orientations are not necessarily equally abundant and that the ratio of
tunnelling currents in twinned and untwinned materials should be related to the
relative abundance of the two twin orientations.Comment: 6 pages, RevTeX 3.0, 15 PostScript figur
Effects of Feeding Bt Maize to Sows during Gestation and Lactation on Maternal and Offspring Immunity and Fate of Transgenic Material
peer-reviewedBackground:
We aimed to determine the effect of feeding transgenic maize to sows during gestation and lactation on maternal and offspring immunity and to assess the fate of transgenic material.
Methodology/Principal Findings:
On the day of insemination, sows were assigned to one of two treatments (n = 12/treatment); 1) non-Bt control maize diet or 2) Bt-MON810 maize diet, which were fed for ~143 days throughout gestation and lactation. Immune function was assessed by leukocyte phenotyping, haematology and Cry1Ab-specific antibody presence in blood on days 0, 28 and 110 of gestation and at the end of lactation. Peripheral-blood mononuclear cell cytokine production was investigated on days 28 and 110 of gestation. Haematological analysis was performed on offspring at birth (n = 12/treatment). Presence of the cry1Ab transgene was assessed in sows' blood and faeces on day 110 of gestation and in blood and tissues of offspring at birth. Cry1Ab protein presence was assessed in sows' blood during gestation and lactation and in tissues of offspring at birth. Blood monocyte count and percentage were higher (P<0.05), while granulocyte percentage was lower (P<0.05) in Bt maize-fed sows on day 110 of gestation. Leukocyte count and granulocyte count and percentage were lower (P<0.05), while lymphocyte percentage was higher (P<0.05) in offspring of Bt maize-fed sows. Bt maize-fed sows had a lower percentage of monocytes on day 28 of lactation and of CD4+CD8+ lymphocytes on day 110 of gestation, day 28 of lactation and overall (P<0.05). Cytokine production was similar between treatments. Transgenic material or Cry1Ab-specific antibodies were not detected in sows or offspring.
Conclusions/Significance:
Treatment differences observed following feeding of Bt maize to sows did not indicate inflammation or allergy and are unlikely to be of major importance. These results provide additional data for Bt maize safety assessment.The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007–2013) under grant agreement number 211820 and the Teagasc Walsh Fellowship Programme
Lithium modulates autophagy in esophageal and colorectal cancer cells and enhances the efficacy of therapeutic agents in vitro and in vivo
Many epithelial cancers, particularly gastrointestinal tract cancers, remain poor prognosis diseases, due to resistance to cytotoxic therapy and local or metastatic recurrence. We have previously shown that apoptosis incompetent esophageal cancer cells induce autophagy in response to chemotherapeutic agents and this can facilitate their recovery. However, known pharmacological inhibitors of autophagy could not enhance cytotoxicity. In this study, we have examined two well known, clinically approved autophagy inducers, rapamycin and lithium, for their effects on chemosensitivity in apoptosis incompetent cancer cells. Both lithium and rapamycin were shown to induce autophagosomes in esophageal and colorectal cancer cells by western blot analysis of LC3 isoforms, morphology and FACS quantitation of Cyto-ID or mCherry-GFP-LC3. Analysis of autophagic flux indicates inefficient autophagosome processing in lithium treated cells, whereas rapamycin treated cells showed efficient flux. Viability and recovery was assessed by clonogenic assays. When combined with the chemotherapeutic agent 5-fluorouracil, rapamycin was protective. In contrast, lithium showed strong enhancement of non-apoptotic cell death. The combination of lithium with 5-fluorouracil or oxaliplatin was then tested in the syngenic mouse (balb/c) colorectal cancer model-CT26. When either chemotherapeutic agent was combined with lithium a significant reduction in tumor volume was achieved. In addition, survival was dramatically increased in the combination group (p 50% of animals achieving long term cure without re-occurrence (> 1 year tumor free). Thus, combination treatment with lithium can substantially improve the efficacy of chemotherapeutic agents in apoptosis deficient cancer cells. Induction of compromised autophagy may contribute to this cytotoxicity
On the Apparent Orbital Inclination Change of the Extrasolar Transiting Planet TrES-2b
On June 15, 2009 UT the transit of TrES-2b was detected using the University
of Arizona's 1.55 meter Kuiper Telescope with 2.0-2.5 millimag RMS accuracy in
the I-band. We find a central transit time of
HJD, an orbital period of days, and an
inclination angle of , which is consistent with our
re-fit of the original I-band light curve of O'Donovan et al. (2006) where we
find . We calculate an insignificant inclination
change of over the last 3 years, and as
such, our observations rule out, at the level, the apparent
change of orbital inclination to as
predicted by Mislis and Schmitt (2009) and Mislis et al. (2010) for our epoch.
Moreover, our analysis of a recently published Kepler Space Telescope light
curve (Gilliland et al. 2010) for TrES-2b finds an inclination of for a similar epoch. These Kepler results definitively
rule out change in as a function of time. Indeed, we detect no significant
changes in any of the orbital parameters of TrES-2b.Comment: 19 pages, 1 table, 7 figures. Re-submitted to ApJ, January 14, 201
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